2MOE

Solution structure of MBD4 methyl-cytosine binding domain bound to methylated DNA

2MOE の概要

• エントリーDOI: 10.2210/pdb2moe/pdb
• NMR情報: BMRB: 19939
• 分子名称: Methyl-CpG-binding domain protein 4, DNA (5'-D(*GP*GP*AP*TP*(5CM)P*GP*GP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*CP*(5CM)P*GP*AP*TP*CP*C)-3') (3 entities in total)
• 機能のキーワード: protein/dna, methylated dna, hydrolase-dna complex, hydrolase/dna
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: O95243
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 14207.29

構造登録者

Williams, D.C.,Walavalkar, N.M. (登録日: 2014-04-24, 公開日: 2014-09-10, 最終更新日: 2024-05-15)

• 主引用文献: Walavalkar, N.M.,Cramer, J.M.,Buchwald, W.A.,Scarsdale, J.N.,Williams, D.C.; Solution structure and intramolecular exchange of methyl-cytosine binding domain protein 4 (MBD4) on DNA suggests a mechanism to scan for mCpG/TpG mismatches.; Nucleic Acids Res., 42:11218-11232, 2015; PubMed: 25183517; DOI: 10.1093/nar/gku782

実験手法

SOLUTION NMR