2MHX

Structure of Exocyclic R,R N6,N6-(2,3-Dihydroxy-1,4-butadiyl)-2'-Deoxyadenosine Adduct Induced by 1,2,3,4-Diepoxybutane in DNA

Summary for 2MHX

• Entry DOI: 10.2210/pdb2mhx/pdb
• NMR Information: BMRB: 19659
• Descriptor: 5'-D(*CP*GP*GP*AP*CP*(RBD)P*AP*GP*AP*AP*G)-3'), 5'-D(*CP*TP*TP*CP*TP*TP*GP*TP*CP*CP*G)-3') (2 entities in total)
• Functional Keywords: b-form dna, 11-mer, deb induced adduct, dhb-da adduct, n-ras codon 61 sequence, dna
• Total number of polymer chains: 2
• Total formula weight: 6795.51

Authors

Kowal, E.A.,Seneviratne, U.,Wickramaratne, S.,Doherty, K.E.,Cao, X.,Tretyakova, N.,Stone, M.P. (deposition date: 2013-12-05, release date: 2014-05-28, Last modification date: 2014-06-04)

• Primary citation: Kowal, E.A.,Seneviratne, U.,Wickramaratne, S.,Doherty, K.E.,Cao, X.,Tretyakova, N.,Stone, M.P.; Structures of Exocyclic R,R- and S,S-N(6),N(6)-(2,3-Dihydroxybutan-1,4-diyl)-2'-Deoxyadenosine Adducts Induced by 1,2,3,4-Diepoxybutane.; Chem.Res.Toxicol., 27:805-817, 2014; PubMed: 24741991; DOI: 10.1021/tx400472p

Experimental method

SOLUTION NMR