2MFM

Solution structure of the C-terminally encoded peptide of the plant parasitic nematode Meloidogyne hapla - CEP11

Summary for 2MFM

• Entry DOI: 10.2210/pdb2mfm/pdb
• Related: 2MFO
• NMR Information: BMRB: 19555
• Descriptor: CEP11 (1 entity in total)
• Functional Keywords: cep, meloidogyne, root-knot nematode, cle, hormone
• Biological source: Meloidogyne hapla
• Total number of polymer chains: 1
• Total formula weight: 1522.64

Authors

Bobay, B.G.,DiGennaro, P.,Bird, D.M. (deposition date: 2013-10-14, release date: 2013-12-11, Last modification date: 2025-03-26)

Primary citation

Bobay, B.G.,Digennaro, P.,Scholl, E.,Imin, N.,Djordjevic, M.A.,McK Bird, D.
Solution NMR studies of the plant peptide hormone CEP inform function.
Febs Lett., 587:3979-3985, 2013

PubMed Abstract: The C-terminally Encoded Peptide (CEP) family of regulatory peptides controls root development in vascular plants. Here, we present the first NMR structures of CEP. We show that root-knot nematode (RKN: Meloidogyne spp.) also encodes CEP, presumably to mimic plant CEP as part of their stereotypic, parasitic interaction with vascular plants. Molecular dynamics simulations of plant- and nematode-encoded CEP displaying known posttranslational modifications (PTM) provided insight into the structural effects of PTM and the conformational plasticity and rigidity of CEP. Potential mechanisms of action are discussed with respect to the structure and sampling of conformational space.

PubMed: 24211833
DOI: 10.1016/j.febslet.2013.10.033

Experimental method

SOLUTION NMR