HIV-1 gp41 clade C Membrane Proximal External Region peptide in DPC micelle

Summary for 2ME3

Related2PV6 2ME1 2ME2 2ME4
DescriptorEnvelope glycoprotein gp160 (1 entity in total)
Functional Keywordsmper, viral fusion, helix-hinge-helix, membrane protein
Biological sourceHuman immunodeficiency virus 1
Cellular locationVirion membrane; Single-pass type I membrane protein Q202K4
Total number of polymer chains1
Total molecular weight3514.02
Sun, Z.J.,Wagner, G.,Reinherz, E.L.,Kim, M.,Song, L.,Choi, J.,Cheng, Y.,Chowdhury, B.,Bellot, G.,Shih, W. (deposition date: 2013-09-20, release date: 2013-10-09, Last modification date: 2014-03-05)
Primary citation
Sun, Z.Y.,Cheng, Y.,Kim, M.,Song, L.,Choi, J.,Kudahl, U.J.,Brusic, V.,Chowdhury, B.,Yu, L.,Seaman, M.S.,Bellot, G.,Shih, W.M.,Wagner, G.,Reinherz, E.L.
Disruption of Helix-Capping Residues 671 and 674 Reveals a Role in HIV-1 Entry for a Specialized Hinge Segment of the Membrane Proximal External Region of gp41.
J.Mol.Biol., 426:1095-1108, 2014
PubMed: 24075869 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2013.09.030
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers221.5%45.0%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures