2MBF
Solution structure of the forkhead domain of Brugia malayi DAF-16a
Summary for 2MBF
| Entry DOI | 10.2210/pdb2mbf/pdb |
| NMR Information | BMRB: 19398 |
| Descriptor | Fork head domain containing protein (1 entity in total) |
| Functional Keywords | forkhead, foxo, foxo3a, winged helix, insulin/igf-1 signaling, filarial parasites, transcription |
| Biological source | Brugia malayi (agent of lymphatic filariasis) |
| Total number of polymer chains | 1 |
| Total formula weight | 11672.98 |
| Authors | Veldkamp, C.T.,Peterson, F.C.,Casper, S.K.,Schoeller, S.J. (deposition date: 2013-07-30, release date: 2013-09-11, Last modification date: 2024-05-15) |
| Primary citation | Casper, S.K.,Schoeller, S.J.,Zgoba, D.M.,Phillips, A.J.,Morien, T.J.,Chaffee, G.R.,Sackett, P.C.,Peterson, F.C.,Crossgrove, K.,Veldkamp, C.T. The solution structure of the forkhead box-O DNA binding domain of Brugia malayi DAF-16a. Proteins, 82:3490-3496, 2014 Cited by PubMed Abstract: Brugia malayi is a parasitic nematode that causes lymphatic filariasis in humans. Here the solution structure of the forkhead DNA binding domain of Brugia malayi DAF-16a, a putative ortholog of Caenorhabditis elegans DAF-16, is reported. It is believed to be the first structure of a forkhead or winged helix domain from an invertebrate. C. elegans DAF-16 is involved in the insulin/IGF-I signaling pathway and helps control metabolism, longevity, and development. Conservation of sequence and structure with human FOXO proteins suggests that B. malayi DAF-16a is a member of the FOXO family of forkhead proteins. PubMed: 25297652DOI: 10.1002/prot.24701 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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