2MAR
Solution structure of Ani s 5 Anisakis simplex allergen
Summary for 2MAR
| Entry DOI | 10.2210/pdb2mar/pdb |
| NMR Information | BMRB: 19372 |
| Descriptor | SXP/RAL-2 family protein (1 entity in total) |
| Functional Keywords | unknown function |
| Biological source | Anisakis simplex (Herring worm) |
| Total number of polymer chains | 1 |
| Total formula weight | 14759.72 |
| Authors | Garcia-Mayoral, M.F.,Trevino, M.A.,Perez-Pinar, T.,Caballero, M.L.,Knaute, T.,Umpierrez, A.,Bruix, M.,Rodriguez-Perez, R. (deposition date: 2013-07-17, release date: 2014-07-02, Last modification date: 2024-05-15) |
| Primary citation | Garcia-Mayoral, M.F.,Trevino, M.A.,Perez-Pinar, T.,Caballero, M.L.,Knaute, T.,Umpierrez, A.,Bruix, M.,Rodriguez-Perez, R. Relationships between IgE/IgG4 epitopes, structure and function in Anisakis simplex Ani s 5, a member of the SXP/RAL-2 protein family Plos Negl Trop Dis, 8:e2735-e2735, 2014 Cited by PubMed Abstract: Anisakiasis is a re-emerging global disease caused by consumption of raw or lightly cooked fish contaminated with L3 Anisakis larvae. This zoonotic disease is characterized by severe gastrointestinal and/or allergic symptoms which may misdiagnosed as appendicitis, gastric ulcer or other food allergies. The Anisakis allergen Ani s 5 is a protein belonging to the SXP/RAL-2 family; it is detected exclusively in nematodes. Previous studies showed that SXP/RAL-2 proteins are active antigens; however, their structure and function remain unknown. The aim of this study was to elucidate the three-dimensional structure of Ani s 5 and its main IgE and IgG4 binding regions. PubMed: 24603892DOI: 10.1371/journal.pntd.0002735 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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