2M7A
Enteropathogenic Escherichia coli 0111:H- str. 11128 ORF EC0111_1119 similar to bacteriophage lambda ea8.5
Summary for 2M7A
| Entry DOI | 10.2210/pdb2m7a/pdb |
| Related | 2M7B |
| NMR Information | BMRB: 19178 |
| Descriptor | Uncharacterized protein, ZINC ION (2 entities in total) |
| Functional Keywords | bacteriophage, zinc binding, chcc motif, unknown function |
| Biological source | Escherichia coli (Escherichia coli) |
| Total number of polymer chains | 1 |
| Total formula weight | 11391.98 |
| Authors | Donaldson, L.W.F. (deposition date: 2013-04-18, release date: 2013-06-12, Last modification date: 2024-05-01) |
| Primary citation | Kwan, J.J.,Smirnova, E.,Khazai, S.,Evanics, F.,Maxwell, K.L.,Donaldson, L.W. The Solution Structures of Two Prophage Homologues of the Bacteriophage lambda Ea8.5 Protein Reveal a Newly Discovered Hybrid Homeodomain/Zinc-Finger Fold. Biochemistry, 52:3612-3614, 2013 Cited by PubMed Abstract: A cluster of genes in the exoxis region of bacteriophage λ are capable of inhibiting the initiation of DNA synthesis in Escherichia coli. The most indispensible gene in this region is ea8.5. Here, we report the nuclear magnetic resonance structures of two ea8.5 orthologs from enteropathogenic E. coli and Pseudomonas putida prophages. Both proteins are characterized by a fused homeodomain/zinc-finger fold that escaped detection by primary sequence search methods. While these folds are both associated with a nucleic acid binding function, the amino acid composition suggests otherwise, leading to the possibility that Ea8.5 associates with other viral and host proteins. PubMed: 23672713DOI: 10.1021/bi400543w PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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