2M20
EGFR transmembrane - juxtamembrane (TM-JM) segment in bicelles: MD guided NMR refined structure.
Summary for 2M20
Entry DOI | 10.2210/pdb2m20/pdb |
NMR Information | BMRB: 18888 |
Descriptor | Epidermal growth factor receptor (1 entity in total) |
Functional Keywords | transmembrane, cell signaling, juxtamembrane, signaling protein |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 2 |
Total formula weight | 13558.50 |
Authors | Endres, N.F.,Das, R.,Smith, A.,Arkhipov, A.,Kovacs, E.,Huang, Y.,Pelton, J.G.,Shan, Y.,Shaw, D.E.,Wemmer, D.E.,Groves, J.T.,Kuriyan, J. (deposition date: 2012-12-11, release date: 2013-02-20, Last modification date: 2024-05-01) |
Primary citation | Endres, N.F.,Das, R.,Smith, A.W.,Arkhipov, A.,Kovacs, E.,Huang, Y.,Pelton, J.G.,Shan, Y.,Shaw, D.E.,Wemmer, D.E.,Groves, J.T.,Kuriyan, J. Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor. Cell(Cambridge,Mass.), 152:543-556, 2013 Cited by PubMed: 23374349DOI: 10.1016/j.cell.2012.12.032 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
Download full validation report