2LZG

NMR Structure of Mdm2 (6-125) with Pip-1

Summary for 2LZG

Entry DOI	10.2210/pdb2lzg/pdb
NMR Information	BMRB: 18755
Descriptor	E3 ubiquitin-protein ligase Mdm2, [(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetic acid (2 entities in total)
Functional Keywords	mdm2, oncogene protein-inhibitor complex, protein binding
Biological source	Homo sapiens (human)
Cellular location	Nucleus, nucleoplasm: Q00987
Total number of polymer chains	1
Total formula weight	14591.52
Authors	Michelsen, K.B.,Jordan, J.B.,Lewis, J.,Long, A.M.,Yang, E.,Rew, Y.,Zhou, J.,Yakowec, P.,Schnier, P.D.,Huang, X.,Poppe, L. (deposition date: 2012-10-02, release date: 2012-11-07, Last modification date: 2024-05-01)
Primary citation	Michelsen, K.,Jordan, J.B.,Lewis, J.,Long, A.M.,Yang, E.,Rew, Y.,Zhou, J.,Yakowec, P.,Schnier, P.D.,Huang, X.,Poppe, L. Ordering of the N-Terminus of Human MDM2 by Small Molecule Inhibitors. J.Am.Chem.Soc., 134:17059-17067, 2012 Cited by PubMed: 22991965 DOI: 10.1021/ja305839b PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation