2L24

Antimicrobial peptide

Summary for 2L24

Entry DOI	10.2210/pdb2l24/pdb
Descriptor	Hemagglutinin (1 entity in total)
Functional Keywords	antimicrobial peptide, design, hemagglutinin, antimicrobial protein
Biological source	Influenza A virus
Total number of polymer chains	1
Total formula weight	1448.75
Authors	Zhu, S.,Aumelas, A.,Gao, B. (deposition date: 2010-08-10, release date: 2011-06-22, Last modification date: 2024-10-30)
Primary citation	Zhu, S.,Aumelas, A.,Gao, B. Convergent evolution-guided design of antimicrobial peptides derived from influenza A virus hemagglutinin. J.Med.Chem., 54:1091-1095, 2011 Cited by PubMed Abstract: Antimicrobial activity and solution structures of four 13-amino acid peptides derived from the fusion domain of viral hemagglutinin proteins are presented. The results show that carboxyl-terminal amidation is a key factor to switch a viral fusion domain-derived sequence into an antimicrobial peptide. Optimization of amphiphilic balance on the amidated analogue largely improves efficacy and enlarges antimicrobial spectra of these peptides. Our work indicates that viral fusion domains have potential to be engineered into potent antimicrobial peptides. PubMed: 21222457 DOI: 10.1021/jm1010463 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation