2KYA

Solution structure of the leader sequence of the patellamide precursor peptide, PatE1-34

Summary for 2KYA

Entry DOI	10.2210/pdb2kya/pdb
NMR Information	BMRB: 16943
Descriptor	Patellamide protein (1 entity in total)
Functional Keywords	cyclic peptides, pate, patellamides, prochloron, ribosomal peptide synthetase, unknown function
Biological source	Prochloron didemni
Total number of polymer chains	1
Total formula weight	3709.25
Authors	Houssen, W.E.,Wright, S.H.,Kalverda, A.P.,Thompson, G.S.,Kelly, S.M.,Jaspars, M. (deposition date: 2010-05-21, release date: 2010-09-01, Last modification date: 2024-05-01)
Primary citation	Houssen, W.E.,Wright, S.H.,Kalverda, A.P.,Thompson, G.S.,Kelly, S.M.,Jaspars, M. Solution Structure of the Leader Sequence of the Patellamide Precursor Peptide, PatE(1-34). Chembiochem, 11:1867-1873, 2010 Cited by PubMed Abstract: The solution structure of the leader sequence of the patellamide precursor peptide was analysed by using CD and determined with NOE-restrained molecular dynamics calculations. This leader sequence is highly conserved in the precursor peptides of some other cyanobactins harbouring heterocycles, and is assumed to play a role in targeting the precursor peptide to the post-translational machinery. The sequence was observed to form an alpha-helix spanning residues 13-28 with a hydrophobic surface on one side of the helix. This hydrophobic surface is proposed to be the site of the initial binding with modifying enzymes. PubMed: 20715266 DOI: 10.1002/cbic.201000305 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation