2KU0

Inhibitor Induced Structural Change in the HCV IRES Domain IIa RNA

Summary for 2KU0

• Entry DOI: 10.2210/pdb2ku0/pdb
• Related: 2KTZ
• Descriptor: HCV IRES Domain IIa RNA, (7S)-7-[(dimethylamino)methyl]-1-[3-(dimethylamino)propyl]-7,8-dihydro-1H-furo[3,2-e]benzimidazol-2-amine (2 entities in total)
• Functional Keywords: hepatitis c virus, rna structure, antiviral, rna
• Biological source: Hepatitis C virus (HCV)
• Total number of polymer chains: 1
• Total formula weight: 12439.60

Authors

Paulsen, R.B.,Seth, P.P.,Swayze, E.E.,Griffey, R.H.,Skalicky, J.J.,Cheatham III, T.E.,Davis, D.R. (deposition date: 2010-02-10, release date: 2010-04-28, Last modification date: 2022-03-16)

• Primary citation: Paulsen, R.B.,Seth, P.P.,Swayze, E.E.,Griffey, R.H.,Skalicky, J.J.,Cheatham, T.E.,Davis, D.R.; Inhibitor-induced structural change in the HCV IRES domain IIa RNA.; Proc.Natl.Acad.Sci.USA, 107:7263-7268, 2010; PubMed: 20360559; DOI: 10.1073/pnas.0911896107

Experimental method

SOLUTION NMR