2KTT

Solution Structure of a Covalently Bound Pyrrolo[2,1-c][1,4]benzodiazepine-Benzimidazole Hybrid to a 10mer DNA Duplex

Summary for 2KTT

• Entry DOI: 10.2210/pdb2ktt/pdb
• Descriptor: 5'-D(*AP*AP*CP*AP*AP*TP*TP*GP*TP*T)-3', (11aS)-7-methoxy-8-(3-{4-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]phenoxy}propoxy)-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one (2 entities in total)
• Functional Keywords: dna duplex, pyrrolobenzodiazepine, pbd-benzimidazole hybrid, dna-drug complex, dna
• Total number of polymer chains: 2
• Total formula weight: 6682.78

Authors

Rettig, M.,Weingarth, M.,Langel, W.,Kamal, A.,Kumar, P.P.,Weisz, K. (deposition date: 2010-02-08, release date: 2010-03-09, Last modification date: 2024-05-01)

• Primary citation: Rettig, M.,Weingarth, M.,Langel, W.,Kamal, A.,Kumar, P.P.,Weisz, K.; Solution structure of a covalently bound pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole hybrid to a 10mer DNA duplex.; Biochemistry, 48:12223-12232, 2009; PubMed: 19911838; DOI: 10.1021/bi901655t

Experimental method

SOLUTION NMR