2KTT
Solution Structure of a Covalently Bound Pyrrolo[2,1-c][1,4]benzodiazepine-Benzimidazole Hybrid to a 10mer DNA Duplex
Summary for 2KTT
Entry DOI | 10.2210/pdb2ktt/pdb |
Descriptor | 5'-D(*AP*AP*CP*AP*AP*TP*TP*GP*TP*T)-3', (11aS)-7-methoxy-8-(3-{4-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]phenoxy}propoxy)-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one (2 entities in total) |
Functional Keywords | dna duplex, pyrrolobenzodiazepine, pbd-benzimidazole hybrid, dna-drug complex, dna |
Total number of polymer chains | 2 |
Total formula weight | 6682.78 |
Authors | Rettig, M.,Weingarth, M.,Langel, W.,Kamal, A.,Kumar, P.P.,Weisz, K. (deposition date: 2010-02-08, release date: 2010-03-09, Last modification date: 2024-05-01) |
Primary citation | Rettig, M.,Weingarth, M.,Langel, W.,Kamal, A.,Kumar, P.P.,Weisz, K. Solution structure of a covalently bound pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole hybrid to a 10mer DNA duplex. Biochemistry, 48:12223-12232, 2009 Cited by PubMed: 19911838DOI: 10.1021/bi901655t PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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