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2KNA

Solution structure of UBA domain of XIAP

Summary for 2KNA
Entry DOI10.2210/pdb2kna/pdb
NMR InformationBMRB: 16478
DescriptorBaculoviral IAP repeat-containing protein 4 (1 entity in total)
Functional Keywordsxiap, uba, apoptosis, ligase, metal-binding, phosphoprotein, protease inhibitor, thiol protease inhibitor, ubl conjugation pathway, zinc-finger
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P98170
Total number of polymer chains1
Total formula weight11873.37
Authors
Hui, S.K.,Tse, M.K.,Sze, K.H. (deposition date: 2009-08-20, release date: 2010-09-01, Last modification date: 2024-05-01)
Primary citationHui, S.K.,Tse, M.K.,Yang, Y.,Wong, B.C.,Sze, K.H.
Backbone and side-chain 1H, 13C and 15N assignments of the ubiquitin-associated domain of human X-linked inhibitor of apoptosis protein
Biomol.Nmr Assign., 4:13-15, 2010
Cited by
PubMed Abstract: X-linked inhibitor of apoptosis protein (XIAP), a leading member of the family of inhibitor of apoptosis (IAP) proteins, is considered as the most potent and versatile inhibitor of caspases and apoptosis. It has been reported that XIAP is frequently overexpressed in cancer and its expression level is implicated in contributing to tumorigenesis, disease progression, chemoresistance and poor patient-survival. Therefore, XIAP is one of the leading targets in drug development for cancer therapy. Recently, based on bioinformatics study, a previously unrecognized but evolutionarily conserved ubiquitin-associated (UBA) domain in IAPs was identified. The UBA domain is found to be essential for the oncogenic potential of IAP, to maintain endothelial cell survival and to protect cells from TNF-alpha-induced apoptosis. Moreover, the UBA domain is required for XIAP to activate NF-kappaB. In the present study, we report the near complete resonance assignments of the UBA domain-containing region of human XIAP protein. Secondary structure prediction based on chemical shift index (CSI) analysis reveals that the protein is predominately alpha-helical, which is consistent with the structures of known UBA proteins.
PubMed: 19916060
DOI: 10.1007/s12104-009-9197-x
PDB entries with the same primary citation
Experimental method
SOLUTION NMR
Structure validation

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