2KI9
Human cannabinoid receptor-2 helix 6
Summary for 2KI9
| Entry DOI | 10.2210/pdb2ki9/pdb |
| NMR Information | BMRB: 16268 |
| Descriptor | Cannabinoid receptor 2 (1 entity in total) |
| Functional Keywords | human cannabinoid receptor-2, gpcr, g-protein coupled receptor, membrane protein |
| Cellular location | Cell membrane; Multi-pass membrane protein: P34972 |
| Total number of polymer chains | 1 |
| Total formula weight | 3553.39 |
| Authors | Deshmukh, L.,Vinogradova, O.,Tiburu, E.K.,Tyukhtenko, S.,Janero, D.R.,Makriyannis, A. (deposition date: 2009-04-28, release date: 2009-05-12, Last modification date: 2024-05-22) |
| Primary citation | Tiburu, E.K.,Tyukhtenko, S.,Deshmukh, L.,Vinogradova, O.,Janero, D.R.,Makriyannis, A. Structural biology of human cannabinoid receptor-2 helix 6 in membrane-mimetic environments. Biochem.Biophys.Res.Commun., 384:243-248, 2009 Cited by PubMed Abstract: We detail the structure and dynamics of a synthetic peptide corresponding to transmembrane helix 6 (TMH6) of human cannabinoid receptor-2 (hCB2) in biomembrane-mimetic environments. The peptide's NMR structural biology is characterized by two alpha-helical domains bridged by a flexible, nonhelical hinge region containing a highly-conserved CWFP motif with an environmentally sensitive, Pro-based conformational switch. Buried within the peptide's flexible region, W(258) may hydrogen-bond with L(255) to help stabilize the Pro-kinked hCB2 TMH6 structure and position C(257) advantageously for interaction with agonist ligands. These characteristics of hCB2 TMH6 are potential structural features of ligand-induced hCB2 activation in vivo. PubMed: 19397896DOI: 10.1016/j.bbrc.2009.04.099 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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