2KGP

Structural basis for stabilization of the tau pre-mRNA splicing regulatory element by Novantrone (Mitoxantrone)

Summary for 2KGP

• Entry DOI: 10.2210/pdb2kgp/pdb
• Descriptor: RNA (25-MER), 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE (2 entities in total)
• Functional Keywords: tau pre-mrna, splicing regulatory element, mitoxantrone, novantrone, rna-small molecule, tauopathies, rna
• Total number of polymer chains: 1
• Total formula weight: 8435.26

Authors

Zheng, S.,Chen, Y.,Donahue, C.P.,Wolfe, M.S.,Varani, G. (deposition date: 2009-03-13, release date: 2009-06-02, Last modification date: 2024-05-01)

• Primary citation: Zheng, S.,Chen, Y.,Donahue, C.P.,Wolfe, M.S.,Varani, G.; Structural basis for stabilization of the tau pre-mRNA splicing regulatory element by novantrone (mitoxantrone).; Chem.Biol., 16:557-566, 2009; PubMed: 19477420; DOI: 10.1016/j.chembiol.2009.03.009

Experimental method

SOLUTION NMR