2KGK

Solution structure of Bacillus anthracis dihydrofolate reductase

2KGK の概要

• エントリーDOI: 10.2210/pdb2kgk/pdb
• NMR情報: BMRB: 16822
• 分子名称: Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine (3 entities in total)
• 機能のキーワード: dhfr, oxidoreductase
• 由来する生物種: Bacillus anthracis (anthrax,anthrax bacterium)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 21552.07

構造登録者

Deshmukh, L.,Vinogradova, O.,Beierlein, J.M.,Frey, K.M.,Anderson, A.C. (登録日: 2009-03-12, 公開日: 2009-05-12, 最終更新日: 2024-05-22)

• 主引用文献: Beierlein, J.M.,Deshmukh, L.,Frey, K.M.,Vinogradova, O.,Anderson, A.C.; The solution structure of Bacillus anthracis dihydrofolate reductase yields insight into the analysis of structure-activity relationships for novel inhibitors.; Biochemistry, 48:4100-4108, 2009; PubMed: 19323450; DOI: 10.1021/bi802319w

実験手法

SOLUTION NMR