2KFX
Structure of the N-terminal domain of human cardiac troponin C bound to calcium ion and to the inhibitor W7
Summary for 2KFX
Entry DOI | 10.2210/pdb2kfx/pdb |
NMR Information | BMRB: 16190 |
Descriptor | Troponin C, slow skeletal and cardiac muscles, CALCIUM ION, N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE (3 entities in total) |
Functional Keywords | calcium regulation, striated muscle, cardiac, troponin, w7, cardiotonic drugs, acetylation, calcium, cardiomyopathy, disease mutation, muscle protein, polymorphism, metal binding protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 10419.12 |
Authors | Hoffman, R.M.B.,Sykes, B.D. (deposition date: 2009-02-28, release date: 2009-06-09, Last modification date: 2024-05-22) |
Primary citation | Hoffman, R.M.,Sykes, B.D. Structure of the inhibitor W7 bound to the regulatory domain of cardiac troponin C. Biochemistry, 48:5541-5552, 2009 Cited by PubMed: 19419198DOI: 10.1021/bi9001826 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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