2KDU

Structural basis of the Munc13-1/Ca2+-Calmodulin interaction: A novel 1-26 calmodulin binding motif with a bipartite binding mode

Summary for 2KDU

• Entry DOI: 10.2210/pdb2kdu/pdb
• Descriptor: Calmodulin, Protein unc-13 homolog A, CALCIUM ION (3 entities in total)
• Functional Keywords: protein, calmodulin, munc13, calcium, acetylation, methylation, alternative splicing, cell junction, cell membrane, coiled coil, cytoplasm, exocytosis, membrane, metal-binding, phorbol-ester binding, phosphoprotein, synapse, zinc, zinc-finger, metal binding protein-protein binding complex, metal binding protein-exocytosis complex, metal binding protein/exocytosis
• Biological source: Xenopus laevis (clawed frog,common platanna,platanna)
• Cellular location: Cytoplasm: Q62768
• Total number of polymer chains: 2
• Total formula weight: 21058.49

Authors

Rodriguez-Castaneda, F.A.,Maestre-Martinez, M.,Coudevylle, N.,Dimova, K.,Jahn, O.,Junge, H.,Becker, S.,Brose, N.,Carlomagno, T.,Griesinger, C. (deposition date: 2009-01-19, release date: 2009-12-15, Last modification date: 2022-03-16)

• Primary citation: Rodriguez-Castaneda, F.,Maestre-Martinez, M.,Coudevylle, N.,Dimova, K.,Junge, H.,Lipstein, N.,Lee, D.,Becker, S.,Brose, N.,Jahn, O.,Carlomagno, T.,Griesinger, C.; Modular architecture of Munc13/calmodulin complexes: dual regulation by Ca2+ and possible function in short-term synaptic plasticity.; Embo J., 29:680-691, 2010; PubMed: 20010694; DOI: 10.1038/emboj.2009.373

Experimental method

SOLUTION NMR