2KAW
NMR structure of the mDvl1 PDZ domain in complex with its inhibitor
Summary for 2KAW
| Entry DOI | 10.2210/pdb2kaw/pdb |
| Related | 1l6o 1mc7 |
| Descriptor | Segment polarity protein dishevelled homolog DVL-1, [(1Z)-5-fluoro-2-methyl-1-{4-[methylsulfinyl]benzylidene}-1H-inden-3-yl]acetic acid (2 entities in total) |
| Functional Keywords | inhibitor of protein-protein interactions, protein structure, pdz domain, wnt signaling, developmental protein, wnt signaling pathway, signaling protein |
| Biological source | Mus musculus (mouse) |
| Cellular location | Cell membrane; Peripheral membrane protein; Cytoplasmic side: P51141 |
| Total number of polymer chains | 1 |
| Total formula weight | 9989.30 |
| Authors | Lee, H.J.,Shao, Y.,Wang, N.X.,Shi, D.L.,Zheng, J.J. (deposition date: 2008-11-17, release date: 2009-09-15, Last modification date: 2011-07-13) |
| Primary citation | Lee, H.J.,Wang, N.X.,Shi, D.L.,Zheng, J.J. Sulindac inhibits canonical Wnt signaling by blocking the PDZ domain of the protein Dishevelled. Angew.Chem.Int.Ed.Engl., 48:6448-6452, 2009 Cited by PubMed: 19637179DOI: 10.1002/anie.200902981 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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