2K9R
Enhancing the activity of insulin by stereospecific unfolding
Summary for 2K9R
Entry DOI | 10.2210/pdb2k9r/pdb |
Related | 2K91 |
Descriptor | Insulin (2 entities in total) |
Functional Keywords | hormone, insulin, mutant, carbohydrate metabolism, cleavage on pair of basic residues, diabetes mellitus, disease mutation, glucose metabolism, pharmaceutical, secreted |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P01308 P01308 |
Total number of polymer chains | 2 |
Total formula weight | 5718.50 |
Authors | Hua, Q.X.,Xu, B.,Huang, K.,Hu, S.Q.,Nakarawa, S.,Jia, W.H.,Philips, N.F.P.,Wittaker, L.,Wittaker, J.,Katsoyannis, P.G.,Weiss, M.A. (deposition date: 2008-10-23, release date: 2008-11-11, Last modification date: 2021-10-20) |
Primary citation | Hua, Q.X.,Xu, B.,Huang, K.,Hu, S.Q.,Nakagawa, S.,Jia, W.,Wang, S.,Whittaker, J.,Katsoyannis, P.G.,Weiss, M.A. Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS. J.Biol.Chem., 284:14586-14596, 2009 Cited by PubMed: 19321436DOI: 10.1074/jbc.M900085200 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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