2K8P

Characterisation of the structural features and interactions of sclerostin: molecular insight into a key regulator of Wnt-mediated bone formation

2K8P の概要

• エントリーDOI: 10.2210/pdb2k8p/pdb
• 分子名称: Sclerostin (1 entity in total)
• 機能のキーワード: wnt signalling pathway, bone formation, alternative splicing, glycoprotein, secreted, signaling protein
• 由来する生物種: Homo sapiens (man)
• 細胞内の位置: Secreted (Potential): Q9BQB4
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 21432.33

構造登録者

Veverka, V.,Henry, A.J.,Slocombe, P.M.,Ventom, A.,Mulloy, B.,Muskett, F.W.,Muzylak, M.,Greenslade, K.,Moore, A.,Zhang, L.,Gong, J.,Qian, X.,Paszty, C.,Taylor, R.J.,Robinson, M.K.,Carr, M.D. (登録日: 2008-09-18, 公開日: 2009-02-17, 最終更新日: 2022-03-16)

• 主引用文献: Veverka, V.,Henry, A.J.,Slocombe, P.M.,Ventom, A.,Mulloy, B.,Muskett, F.W.,Muzylak, M.,Greenslade, K.,Moore, A.,Zhang, L.,Gong, J.,Qian, X.,Paszty, C.,Taylor, R.J.,Robinson, M.K.,Carr, M.D.; Characterization of the Structural Features and Interactions of Sclerostin: Molecular insight into a key regulator of Wnt-mediated bone formation; J.Biol.Chem., 284:10890-10900, 2009; PubMed: 19208630; DOI: 10.1074/jbc.M807994200

実験手法

SOLUTION NMR