2K8F

Structural Basis for the Regulation of p53 Function by p300

2K8F の概要

• エントリーDOI: 10.2210/pdb2k8f/pdb
• NMR情報: BMRB: 15944
• 分子名称: Histone acetyltransferase p300, Cellular tumor antigen p53 (2 entities in total)
• 機能のキーワード: complex of p53 and p300, acetylation, bromodomain, cell cycle, chromosomal rearrangement, citrullination, disease mutation, host-virus interaction, metal-binding, methylation, nucleus, phosphoprotein, polymorphism, transcription, transcription regulation, transferase, zinc, zinc-finger, activator, alternative splicing, anti-oncogene, apoptosis, covalent protein-rna linkage, cytoplasm, dna-binding, endoplasmic reticulum, glycoprotein, li-fraumeni syndrome, ubl conjugation, transferase-transcription complex, transferase/transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cytoplasm: Q09472; Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 14315.56

構造登録者

Bai, Y.,Feng, H.,Jenkins, L.M.,Durell, S.R.,Wiodawer, A.,Appella, E. (登録日: 2008-09-08, 公開日: 2009-03-03, 最終更新日: 2024-05-22)

• 主引用文献: Feng, H.,Jenkins, L.M.,Durell, S.R.,Hayashi, R.,Mazur, S.J.,Cherry, S.,Tropea, J.E.,Miller, M.,Wlodawer, A.,Appella, E.,Bai, Y.; Structural Basis for p300 Taz2-p53 TAD1 Binding and Modulation by Phosphorylation.; Structure, 17:202-210, 2009; PubMed: 19217391; DOI: 10.1016/j.str.2008.12.009

実験手法

SOLUTION NMR