2K79

Solution Structure of the binary complex between the SH3 and SH2 domain of interleukin-2 tyrosine kinase

2K79 の概要

• エントリーDOI: 10.2210/pdb2k79/pdb
• 関連するPDBエントリー: 1awj 1luk 1lun 2etz 2K7A 2rna
• NMR情報: BMRB: 15912
• 分子名称: SH3 domain of Tyrosine-protein kinase ITK/TSK, SH2 domain of Tyrosine-protein kinase ITK/TSK (2 entities in total)
• 機能のキーワード: sh3, sh2, novel, cis, atp-binding, cell membrane, kinase, membrane, metal-binding, nucleotide-binding, phosphoprotein, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase, zinc, zinc-finger
• 由来する生物種: Mus musculus (mouse); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 20034.27

構造登録者

Andreotti, A.H.,Severin, A.J.,Fulton, D.B. (登録日: 2008-08-08, 公開日: 2009-03-10, 最終更新日: 2024-05-01)

• 主引用文献: Severin, A.,Joseph, R.E.,Boyken, S.,Fulton, D.B.,Andreotti, A.H.; Proline isomerization preorganizes the Itk SH2 domain for binding to the Itk SH3 domain.; J.Mol.Biol., 387:726-743, 2009; PubMed: 19361414; DOI: 10.1016/j.jmb.2009.02.012

実験手法

SOLUTION NMR