2K4U

Solution structure of the SCORPION TOXIN ADWX-1

Summary for 2K4U

• Entry DOI: 10.2210/pdb2k4u/pdb
• Descriptor: Potassium channel toxin alpha-KTx 3.6 (1 entity in total)
• Functional Keywords: kv1.1 channel, kv1.3 channel, channel turret, adwx-1 peptide selectivity, structural basis, amidation, ionic channel inhibitor, neurotoxin, potassium channel inhibitor, secreted, toxin
• Biological source: Mesobuthus martensii (Chinese scorpion)
• Cellular location: Secreted: Q9NII7
• Total number of polymer chains: 1
• Total formula weight: 4088.98

Authors

Yin, S.J.,Jiang, L.,Yi, H.,Han, S.,Yang, D.W.,Liu, M.L.,Liu, H.,Cao, Z.J.,Wu, Y.L.,Li, W.X. (deposition date: 2008-06-18, release date: 2008-12-09, Last modification date: 2021-11-10)

• Primary citation: Yin, S.J.,Jiang, L.,Yi, H.,Han, S.,Yang, D.W.,Liu, M.L.,Liu, H.,Cao, Z.J.,Wu, Y.L.,Li, W.X.; Different Residues in Channel Turret Determining the Selectivity of ADWX-1 Inhibitor Peptide between Kv1.1 and Kv1.3 Channels; J.Proteome Res., 7:4890-4897, 2008; PubMed: 18937510; DOI: 10.1021/pr800494a

Experimental method

SOLUTION NMR