2K4L

Solution structure of a 2:1C2-(2-naphthyl)pyrrolo[2,1-c][1,4]benzodiazepine (PBD) DNA adduct: molecular basis for unexpectedly high DNA helix stabilization.

Summary for 2K4L

• Entry DOI: 10.2210/pdb2k4l/pdb
• NMR Information: BMRB: 15613
• Descriptor: 5'-D(*DAP*DAP*DTP*DCP*DTP*DTP*DTP*DAP*DAP*DAP*DGP*DAP*DTP*DT)-3', (11aS)-7,8-dimethoxy-2-naphthalen-2-yl-1,10,11,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one (2 entities in total)
• Functional Keywords: pyrrolo[2, 1-c][1, 4]benzodiazepine, pbd, dna adduct, dna
• Total number of polymer chains: 2
• Total formula weight: 9328.54

Authors

Antonow, D.,Barata, T.,Jenkins, T.C.,Parkinson, G.N.,Howard, P.W.,Thurston, D.E.,Zloh, M. (deposition date: 2008-06-13, release date: 2008-10-28, Last modification date: 2020-02-19)

• Primary citation: Antonow, D.,Barata, T.,Jenkins, T.C.,Parkinson, G.N.,Howard, P.W.,Thurston, D.E.,Zloh, M.; Solution structure of a 2:1 C2-(2-naphthyl) pyrrolo[2,1-c][1,4]benzodiazepine DNA adduct: molecular basis for unexpectedly high DNA helix stabilization.; Biochemistry, 47:11818-11829, 2008; PubMed: 18925745; DOI: 10.1021/bi801225q

Experimental method

SOLUTION NMR