2K4I

Solution structure of HIV-2 myrMA bound to di-C4-PI(4,5)P2

Summary for 2K4I

• Entry DOI: 10.2210/pdb2k4i/pdb
• Related: 2K4E 2K4H
• NMR Information: BMRB: 16889
• Descriptor: HIV-2 myristoylated matrix protein, MYRISTIC ACID, (2R)-3-{[(R)-HYDROXY{[(1R,2R,3S,4R,5R,6S)-2,3,6-TRIHYDROXY-4,5-BIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1,2-DIYL DIBUTANOATE (3 entities in total)
• Functional Keywords: aids, capsid protein, myristate, matrix, gag, hiv, virion, structural protein, plasma membrane
• Biological source: Human immunodeficiency virus type 2 (HIV-2)
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04584
• Total number of polymer chains: 1
• Total formula weight: 15761.98

Authors

Saad, J.S.,Ablan, S.D.,Ghanam, R.H.,Kim, A.,Andrews, K.,Nagashima, K.,Freed, E.O.,Summers, M.F. (deposition date: 2008-06-08, release date: 2008-08-12, Last modification date: 2014-01-29)

• Primary citation: Saad, J.S.,Ablan, S.D.,Ghanam, R.H.,Kim, A.,Andrews, K.,Nagashima, K.,Soheilian, F.,Freed, E.O.,Summers, M.F.; Structure of the myristylated human immunodeficiency virus type 2 matrix protein and the role of phosphatidylinositol-(4,5)-bisphosphate in membrane targeting.; J.Mol.Biol., 382:434-447, 2008; PubMed: 18657545; DOI: 10.1016/j.jmb.2008.07.027

Experimental method

SOLUTION NMR