HADDOCK-derived structure of the CH-domain of the smoothelin-like 1 complexed with the C-domain of apocalmodulin

Summary for 2K3S

Related2JV9 1F71
DescriptorSmoothelin-like protein 1, Calmodulin (2 entities in total)
Functional Keywordsapocalmodulin complex, calponin homology domain, smoothelin-like 1, haddock model, ch-domain, coiled coil, acetylation, calcium, methylation, protein binding
Biological sourceMus musculus (mouse)
Cellular locationCytoplasm, myofibril, sarcomere, I band Q99LM3
Total number of polymer chains2
Total molecular weight21431.26
Ishida, H.,Borman, M.A.,Ostrander, J.,Vogel, H.J.,MacDonald, J.A. (deposition date: 2008-05-15, release date: 2008-05-27, Last modification date: 2011-07-13)
Primary citation
Ishida, H.,Borman, M.A.,Ostrander, J.,Vogel, H.J.,MacDonald, J.A.
Solution structure of the calponin homology (CH) domain from the smoothelin-like 1 protein: a unique apocalmodulin-binding mode and the possible role of the C-terminal type-2 CH-domain in smooth muscle relaxation.
J.Biol.Chem., 283:20569-20578, 2008
PubMed: 18477568 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M800627200
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers30.3%7.4%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
Download full validation report