2K31

Solution Structure of cGMP-binding GAF domain of Phosphodiesterase 5

Summary for 2K31

Entry DOI	10.2210/pdb2k31/pdb
NMR Information	BMRB: 15734
Descriptor	Phosphodiesterase 5A, cGMP-specific, GUANOSINE-3',5'-MONOPHOSPHATE (2 entities in total)
Functional Keywords	cyclic nucleotide phosphodiesterase, pde5, gaf domain, cgmp, hydrolase
Biological source	Mus musculus (mouse)
Total number of polymer chains	1
Total formula weight	20313.68
Authors	Heikaus, C.C.,Stout, J.R.,Sekharan, M.R.,Eakin, C.M.,Rajagopal, P.,Brzovic, P.S.,Beavo, J.A.,Klevit, R.E. (deposition date: 2008-04-16, release date: 2008-06-03, Last modification date: 2021-10-20)
Primary citation	Heikaus, C.C.,Stout, J.R.,Sekharan, M.R.,Eakin, C.M.,Rajagopal, P.,Brzovic, P.S.,Beavo, J.A.,Klevit, R.E. Solution Structure of the cGMP Binding GAF Domain from Phosphodiesterase 5: Insights into Nucleotide Selectivity, Dimerization, and cGMP-Dependent Conformational Change. J.Biol.Chem., 283:22749-22759, 2008 Cited by PubMed: 18534985 DOI: 10.1074/jbc.M801577200 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation