2K31

Solution Structure of cGMP-binding GAF domain of Phosphodiesterase 5

2K31 の概要

• エントリーDOI: 10.2210/pdb2k31/pdb
• NMR情報: BMRB: 15734
• 分子名称: Phosphodiesterase 5A, cGMP-specific, GUANOSINE-3',5'-MONOPHOSPHATE (2 entities in total)
• 機能のキーワード: cyclic nucleotide phosphodiesterase, pde5, gaf domain, cgmp, hydrolase
• 由来する生物種: Mus musculus (mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20313.68

構造登録者

Heikaus, C.C.,Stout, J.R.,Sekharan, M.R.,Eakin, C.M.,Rajagopal, P.,Brzovic, P.S.,Beavo, J.A.,Klevit, R.E. (登録日: 2008-04-16, 公開日: 2008-06-03, 最終更新日: 2021-10-20)

• 主引用文献: Heikaus, C.C.,Stout, J.R.,Sekharan, M.R.,Eakin, C.M.,Rajagopal, P.,Brzovic, P.S.,Beavo, J.A.,Klevit, R.E.; Solution Structure of the cGMP Binding GAF Domain from Phosphodiesterase 5: Insights into Nucleotide Selectivity, Dimerization, and cGMP-Dependent Conformational Change.; J.Biol.Chem., 283:22749-22759, 2008; PubMed: 18534985; DOI: 10.1074/jbc.M801577200

実験手法

SOLUTION NMR