2K04

Structure of SDF1 in complex with the CXCR4 N-terminus containing no sulfotyrosines

2K04 の概要

• エントリーDOI: 10.2210/pdb2k04/pdb
• 関連するPDBエントリー: 2K01 2K03 2K05
• NMR情報: BMRB: 15636
• 分子名称: Stromal cell-derived factor 1, C-X-C chemokine receptor type 4 (2 entities in total)
• 機能のキーワード: stromal cell derived factor-1, sdf1-alpha, cxcl12, cxcr4, chemokine, locked dimer, alternative splicing, chemotaxis, cytokine, growth factor, secreted, g-protein coupled receptor, glycoprotein, host-virus interaction, membrane, receptor, sulfation, transducer, transmembrane
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 25415.06

構造登録者

Volkman, B.F.,Veldkamp, C.T.,Peterson, F.C. (登録日: 2008-01-24, 公開日: 2008-10-28, 最終更新日: 2023-06-14)

• 主引用文献: Veldkamp, C.T.,Seibert, C.,Peterson, F.C.,De la Cruz, N.B.,Haugner, J.C.,Basnet, H.,Sakmar, T.P.,Volkman, B.F.; Structural basis of CXCR4 sulfotyrosine recognition by the chemokine SDF-1/CXCL12; Sci.Signal., 1:ra4-ra4, 2008; PubMed: 18799424; DOI: 10.1126/scisignal.1160755

実験手法

SOLUTION NMR