2JYI
Solution structure of MLL CXXC domain
Summary for 2JYI
Entry DOI | 10.2210/pdb2jyi/pdb |
Related | 2j2s |
Descriptor | Zinc finger protein HRX, ZINC ION (2 entities in total) |
Functional Keywords | protein, cxxc domain, mll, alternative splicing, bromodomain, chromosomal rearrangement, dna-binding, metal-binding, nucleus, phosphoprotein, polymorphism, proto-oncogene, transcription, transcription regulation, ubl conjugation, zinc, zinc-finger |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus. MLL cleavage product N320: Nucleus. MLL cleavage product C180: Nucleus: Q03164 |
Total number of polymer chains | 1 |
Total formula weight | 6664.68 |
Authors | Cierpicki, T.,Bushweller, J.H. (deposition date: 2007-12-13, release date: 2008-12-09, Last modification date: 2024-05-29) |
Primary citation | Cierpicki, T.,Riesbeck, L.E.,Grembecka, J.,Lukasik, S.M.,Omonkowska, M.,Shultis, D.,Zeleznik-Le, N.J.,Bushweller, J.H. Structural basis for maintenance of unmethylated CpG elements by the CXXC domain of MLL and its critical contributions to MLL-AF9 immortalization activity To be Published, |
Experimental method | SOLUTION NMR |
Structure validation
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