2JXY

Solution structure of the hemopexin-like domain of MMP12

Summary for 2JXY

Entry DOI	10.2210/pdb2jxy/pdb
NMR Information	BMRB: 7414,7415,15578
Descriptor	Macrophage metalloelastase, CALCIUM ION (2 entities in total)
Functional Keywords	b-sheet hydrophobic core, calcium, extracellular matrix, glycoprotein, hydrolase, metal-binding, metalloprotease, polymorphism, protease, secreted, zinc, zymogen
Biological source	Homo sapiens (Human)
Cellular location	Secreted, extracellular space, extracellular matrix (Probable): P39900
Total number of polymer chains	1
Total formula weight	23240.53
Authors	Bertini, I.,Calderone, V.,Fragai, M.,Jaiswal, R.,Luchinat, C.,Melikian, M. (deposition date: 2007-12-01, release date: 2008-05-27, Last modification date: 2022-03-16)
Primary citation	Bertini, I.,Calderone, V.,Fragai, M.,Jaiswal, R.,Luchinat, C.,Melikian, M.,Mylonas, E.,Svergun, D.I. Evidence of reciprocal reorientation of the catalytic and hemopexin-like domains of full-length MMP-12 J.Am.Chem.Soc., 130:7011-7021, 2008 Cited by PubMed: 18465858 DOI: 10.1021/ja710491y PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation