2JVE

Solution structure of the extracellular domain of Prod1, a protein implicated in proximodistal identity during amphibian limb regeneration

2JVE の概要

• エントリーDOI: 10.2210/pdb2jve/pdb
• NMR情報: BMRB: 15477
• 分子名称: Prod 1 (1 entity in total)
• 機能のキーワード: ly-6, three-finger snake toxin, upar, cd59, limb regeneration, toxin
• 由来する生物種: Notophthalmus viridescens (red-spotted newt)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 10223.50

構造登録者

Garza-Garcia, A.,Harris, R.,Esposito, D.,Driscoll, P.C. (登録日: 2007-09-19, 公開日: 2008-09-30, 最終更新日: 2024-11-06)

主引用文献

Garza-Garcia, A.,Harris, R.,Esposito, D.,Gates, P.B.,Driscoll, P.C.
Solution structure and phylogenetics of Prod1, a member of the three-finger protein superfamily implicated in salamander limb regeneration.
Plos One, 4:e7123-e7123, 2009

PubMed Abstract: Following the amputation of a limb, newts and salamanders have the capability to regenerate the lost tissues via a complex process that takes place at the site of injury. Initially these cells undergo dedifferentiation to a state competent to regenerate the missing limb structures. Crucially, dedifferentiated cells have memory of their level of origin along the proximodistal (PD) axis of the limb, a property known as positional identity. Notophthalmus viridescens Prod1 is a cell-surface molecule of the three-finger protein (TFP) superfamily involved in the specification of newt limb PD identity. The TFP superfamily is a highly diverse group of metazoan proteins that includes snake venom toxins, mammalian transmembrane receptors and miscellaneous signaling molecules.

PubMed: 19771161
DOI: 10.1371/journal.pone.0007123

実験手法

SOLUTION NMR