2JT6

Solution structure of matrix metalloproteinase 3 (MMP-3) in the presence of 3-4'-cyanobyphenyl-4-yloxy)-n-hdydroxypropionamide (MMP-3 inhibitor VII)

Summary for 2JT6

Related2JNP 2JT5
DescriptorStromelysin-1, ZINC ION, CALCIUM ION, ... (4 entities in total)
Functional Keywordsmetalloproteinase, mmp, calcium, collagen degradation, extracellular matrix, glycoprotein, hydrolase, metal-binding, metalloprotease, polymorphism, protease, zinc, zymogen
Biological sourceHomo sapiens (human)
Cellular locationSecreted, extracellular space, extracellular matrix (Probable) P08254
Total number of polymer chains1
Total molecular weight18536.31
Authors
Alcaraz, L.A.,Banci, L.,Bertini, I.,Cantini, F.,Donaire, A.,Gonnelli, L. (deposition date: 2007-07-23, release date: 2008-02-19, Last modification date: 2011-07-13)
Primary citation
Alcaraz, L.A.,Banci, L.,Bertini, I.,Cantini, F.,Donaire, A.,Gonnelli, L.
Matrix metalloproteinase-inhibitor interaction: the solution structure of the catalytic domain of human matrix metalloproteinase-3 with different inhibitors
J.Biol.Inorg.Chem., 12:1197-1206, 2007
PubMed: 17710450 (PDB entries with the same primary citation)
DOI: 10.1007/s00775-007-0288-9
MImport into Mendeley
Experimental method
SOLUTION NMR
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers103.1%23.0%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
Download full validation report