Solution structure of matrix metalloproteinase 3 (MMP-3) in the presence of 3-4'-cyanobyphenyl-4-yloxy)-n-hdydroxypropionamide (MMP-3 inhibitor VII)

Summary for 2JT6

Related2JNP 2JT5
DescriptorStromelysin-1, ZINC ION, CALCIUM ION, ... (4 entities in total)
Functional Keywordsmetalloproteinase, mmp, calcium, collagen degradation, extracellular matrix, glycoprotein, hydrolase, metal-binding, metalloprotease, polymorphism, protease, zinc, zymogen
Biological sourceHomo sapiens (human)
Cellular locationSecreted, extracellular space, extracellular matrix (Probable) P08254
Total number of polymer chains1
Total molecular weight18536.31
Alcaraz, L.A.,Banci, L.,Bertini, I.,Cantini, F.,Donaire, A.,Gonnelli, L. (deposition date: 2007-07-23, release date: 2008-02-19, Last modification date: 2011-07-13)
Primary citation
Alcaraz, L.A.,Banci, L.,Bertini, I.,Cantini, F.,Donaire, A.,Gonnelli, L.
Matrix metalloproteinase-inhibitor interaction: the solution structure of the catalytic domain of human matrix metalloproteinase-3 with different inhibitors
J.Biol.Inorg.Chem., 12:1197-1206, 2007
PubMed: 17710450 (PDB entries with the same primary citation)
DOI: 10.1007/s00775-007-0288-9
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers103.1%23.0%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
Download full validation report