2JKM
Focal Adhesion Kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor
Summary for 2JKM
Entry DOI | 10.2210/pdb2jkm/pdb |
Related | 1KTM 1PV3 1QVX 2AEH 2AL6 2J0J 2J0K 2J0L 2J0M 2JKK 2JKO 2JKQ |
Descriptor | FOCAL ADHESION KINASE 1, 2-{[5-CHLORO-2-({(1E,4R)-2-METHOXY-4-[(3R)-3-(METHYLAMINO)PYRROLIDIN-1-YL]CYCLOHEXA-2,5-DIEN-1-YLIDENE}AMINO)PYRIMIDIN-4-YL]AMINO}-N-(1-METHYLETHYL)BENZENESULFONAMIDE (3 entities in total) |
Functional Keywords | tyrosine-protein kinase, tyrosine- protein kinase, kinase, membrane, transferase, atp-binding, integrin signaling, nucleotide-binding, focal adhesion, cell migration, kinase inhibitor, cell junction, cell membrane, phosphoprotein |
Biological source | GALLUS GALLUS (CHICKEN) |
Total number of polymer chains | 1 |
Total formula weight | 32322.89 |
Authors | Lietha, D.,Eck, M.J. (deposition date: 2008-08-28, release date: 2008-09-09, Last modification date: 2023-12-13) |
Primary citation | Lietha, D.,Eck, M.J. Crystal Structures of the Fak Kinase in Complex with Tae226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical Dfg Conformation. Plos One, 3:E3800-, 2008 Cited by PubMed: 19030106DOI: 10.1371/JOURNAL.PONE.0003800 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.31 Å) |
Structure validation
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