2JKM
Focal Adhesion Kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | FOCAL ADHESION KINASE 1 | polymer | 276 | 31776.8 | 1 | UniProt (Q00944) Pfam (PF07714) | GALLUS GALLUS (CHICKEN) | PP125FAK |
| 2 | B (A) | 2-{[5-CHLORO-2-({(1E,4R)-2-METHOXY-4-[(3R)-3-(METHYLAMINO)PYRROLIDIN-1-YL]CYCLOHEXA-2,5-DIEN-1-YLIDENE}AMINO)PYRIMIDIN-4-YL]AMINO}-N-(1-METHYLETHYL)BENZENESULFONAMIDE | non-polymer | 546.1 | 1 | Chemie (BII) | |||
| 3 | C (A) | water | water | 18.0 | 72 | Chemie (HOH) |
Sequence modifications
A: 411 - 686 (UniProt: Q00944)
| PDB | External Database | Details |
|---|---|---|
| Tyr 516 | Phe 516 | conflict |
| Ser 556 | Ala 556 | conflict |
| Asn 557 | Thr 557 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31776.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 546.1 | |
| All* | Total formula weight | 32322.9 |
