2JKM

Focal Adhesion Kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor

2JKM の概要

• エントリーDOI: 10.2210/pdb2jkm/pdb
• 関連するPDBエントリー: 1KTM 1PV3 1QVX 2AEH 2AL6 2J0J 2J0K 2J0L 2J0M 2JKK 2JKO 2JKQ
• 分子名称: FOCAL ADHESION KINASE 1, 2-{[5-CHLORO-2-({(1E,4R)-2-METHOXY-4-[(3R)-3-(METHYLAMINO)PYRROLIDIN-1-YL]CYCLOHEXA-2,5-DIEN-1-YLIDENE}AMINO)PYRIMIDIN-4-YL]AMINO}-N-(1-METHYLETHYL)BENZENESULFONAMIDE (3 entities in total)
• 機能のキーワード: tyrosine-protein kinase, tyrosine- protein kinase, kinase, membrane, transferase, atp-binding, integrin signaling, nucleotide-binding, focal adhesion, cell migration, kinase inhibitor, cell junction, cell membrane, phosphoprotein
• 由来する生物種: GALLUS GALLUS (CHICKEN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32322.89

構造登録者

Lietha, D.,Eck, M.J. (登録日: 2008-08-28, 公開日: 2008-09-09, 最終更新日: 2023-12-13)

• 主引用文献: Lietha, D.,Eck, M.J.; Crystal Structures of the Fak Kinase in Complex with Tae226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical Dfg Conformation.; Plos One, 3:E3800-, 2008; PubMed: 19030106; DOI: 10.1371/JOURNAL.PONE.0003800

実験手法

X-RAY DIFFRACTION (2.31 Å)