2JIH
Crystal Structure of Human ADAMTS-1 catalytic Domain and Cysteine- Rich Domain (complex-form)
Summary for 2JIH
Entry DOI | 10.2210/pdb2jih/pdb |
Related | 2V4B |
Descriptor | ADAMTS-1, (2S,3R)-N~4~-[(1S)-2,2-dimethyl-1-(methylcarbamoyl)propyl]-N~1~,2-dihydroxy-3-(2-methylpropyl)butanediamide, ZINC ION, ... (8 entities in total) |
Functional Keywords | zinc, zymogen, protease, adamts-1, hydrolase, metalloprotease, heparin-binding, metalloproteinase, metzincin, polymorphism, glycoprotein, metal-binding, extracellular matrix, cleavage on pair of basic residues |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 2 |
Total formula weight | 68257.07 |
Authors | Gerhardt, S.,Hassall, G.,Hawtin, P.,McCall, E.,Flavell, L.,Minshull, C.,Hargreaves, D.,Ting, A.,Pauptit, R.A.,Parker, A.E.,Abbott, W.M. (deposition date: 2007-06-28, release date: 2008-01-15, Last modification date: 2019-04-24) |
Primary citation | Gerhardt, S.,Hassall, G.,Hawtin, P.,McCall, E.,Flavell, L.,Minshull, C.,Hargreaves, D.,Ting, A.,Pauptit, R.A.,Parker, A.E.,Abbott, W.M. Crystal structures of human ADAMTS-1 reveal a conserved catalytic domain and a disintegrin-like domain with a fold homologous to cysteine-rich domains. J. Mol. Biol., 373:891-902, 2007 Cited by PubMed: 17897672DOI: 10.1016/j.jmb.2007.07.047 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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