2JH6

Human Thrombin Hirugen Inhibitor complex

2JH6 の概要

• エントリーDOI: 10.2210/pdb2jh6/pdb
• 関連するPDBエントリー: 2JH0 2JH5
• 分子名称: THROMBIN LIGHT CHAIN, THROMBIN HEAVY CHAIN, HIRUDIN IIIA, ... (7 entities in total)
• 機能のキーワード: glycoprotein, serine protease, kringle, zymogen, thrombin, protease, disease mutation, blood coagulation, gamma-carboxyglutamic acid, protease inhibitor, serine protease inhibitor, sulfation, acute phase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P28507; Secreted: P00734
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 35753.19

構造登録者

Senger, S.,Chan, C.,Convery, M.A.,Hubbard, J.A.,Young, R.J.,Shah, G.P.,Watson, N.S. (登録日: 2007-02-20, 公開日: 2007-05-08, 最終更新日: 2013-08-07)

• 主引用文献: Senger, S.,Chan, C.,Convery, M.A.,Hubbard, J.A.,Shah, G.P.,Watson, N.S.,Young, R.J.; Sulfonamide-Related Conformational Effects and Their Importance in Structure-Based Design.; Bioorg.Med.Chem.Lett., 17:2931-, 2007; PubMed: 17336062; DOI: 10.1016/J.BMCL.2007.02.034

実験手法

X-RAY DIFFRACTION (2.21 Å)