2JG4

Substrate-free IDE structure in its closed conformation

2JG4 の概要

• エントリーDOI: 10.2210/pdb2jg4/pdb
• 分子名称: INSULIN DEGRADING ENZYME, ZINC ION, 1,4-DIETHYLENE DIOXIDE, ... (4 entities in total)
• 機能のキーワード: hydrolase, metal-binding, metalloprotease, protease, zinc
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 229883.52

構造登録者

Malito, E.,Tang, W.J. (登録日: 2007-02-07, 公開日: 2007-07-03, 最終更新日: 2023-12-13)

• 主引用文献: Im, H.,Manolopoulou, M.,Malito, E.,Shen, Y.,Zhao, J.,Neant-Fery, M.,Sun, C.-Y.,Meredith, S.C.,Sisodia, S.S.,Leissring, M.A.,Tang, W.J.; Structure of Substrate-Free Human Insulin Degrading Enzyme (Ide) and Biophysical Analysis of ATP-Induced Conformational Switch of Ide; J.Biol.Chem., 282:25453-, 2007; PubMed: 17613531; DOI: 10.1074/JBC.M701590200

実験手法

X-RAY DIFFRACTION (2.8 Å)