2JFL

CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE (DIPHOSPHORYLATED FORM) BOUND TO 5- AMINO-3-((4-(AMINOSULFONYL)PHENYL)AMINO)-N-(2,6- DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE

2JFL の概要

• エントリーDOI: 10.2210/pdb2jfl/pdb
• 関連するPDBエントリー: 2J51 2JA0 2JFM
• 分子名称: STE20-LIKE SERINE/THREONINE-PROTEIN KINASE, 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE, 1,2-ETHANEDIOL, ... (6 entities in total)
• 機能のキーワード: transferase, serine/threonine-protein kinase, atp-binding, phosphorylation, muscle development, kinase, apoptosis, germinal centre kinase, serine- threonine kinase 2, nucleotide-binding, serine-threonine-protein kinase
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cytoplasm : Q9H2G2
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38151.34

構造登録者

Pike, A.C.W.,Rellos, P.,Fedorov, O.,Keates, T.,Salah, E.,Savitsky, P.,Papagrigoriou, E.,Bunkoczi, G.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Weigelt, J.,Sundstrom, M.,Knapp, S. (登録日: 2007-02-02, 公開日: 2007-02-27, 最終更新日: 2023-12-13)

• 主引用文献: Pike, A.C.W.,Rellos, P.,Niesen, F.H.,Turnbull, A.,Oliver, A.W.,Parker, S.A.,Turk, B.E.,Pearl, L.H.,Knapp, S.; Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.; Embo J., 27:704-, 2008; PubMed: 18239682; DOI: 10.1038/EMBOJ.2008.8

実験手法

X-RAY DIFFRACTION (2.2 Å)