2JC0

CRYSTAL STRUCTURE OF HEPATITIS C VIRUS POLYMERASE IN COMPLEX WITH INHIBITOR SB655264

Summary for 2JC0

Entry DOI	10.2210/pdb2jc0/pdb
Related	2I1R 2JC1
Descriptor	RNA-DEPENDENT RNA-POLYMERASE, (2S,4S,5R)-2-ISOBUTYL-5-(2-THIENYL)-1-[4-(TRIFLUOROMETHYL)BENZOYL]PYRROLIDINE-2,4-DICARBOXYLIC ACID (3 entities in total)
Functional Keywords	hepatitis, polymerase, hydrolase
Biological source	HEPATITIS C VIRUS
Total number of polymer chains	2
Total formula weight	128543.21
Authors	Wonacott, A.,Skarzynski, T.,Singh, O.M. (deposition date: 2006-12-18, release date: 2007-02-13, Last modification date: 2011-07-13)
Primary citation	Slater, M.J.,Amphlett, E.M.,Andrews, D.M.,Bravi, G.,Burton, G.,Cheasty, A.G.,Corfield, J.A.,Ellis, M.R.,Fenwick, R.H.,Fernandes, S.,Guidetti, R.,Haigh, D.,Hartley, C.D.,Howes, P.D.,Jackson, D.L.,Jarvest, R.L.,Lovegrove, V.L.,Medhurst, K.J.,Parry, N.R.,Price, H.,Shah, P.,Singh, O.M.,Stocker, R.,Thommes, P.,Wilkinson, C.,Wonacott, A. Optimization of Novel Acyl Pyrrolidine Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase Leading to a Development Candidate. J.Med.Chem., 50:897-, 2007 Cited by PubMed: 17269759 DOI: 10.1021/JM061207R PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation