2JC0

CRYSTAL STRUCTURE OF HEPATITIS C VIRUS POLYMERASE IN COMPLEX WITH INHIBITOR SB655264

2JC0 の概要

• エントリーDOI: 10.2210/pdb2jc0/pdb
• 関連するPDBエントリー: 2I1R 2JC1
• 分子名称: RNA-DEPENDENT RNA-POLYMERASE, (2S,4S,5R)-2-ISOBUTYL-5-(2-THIENYL)-1-[4-(TRIFLUOROMETHYL)BENZOYL]PYRROLIDINE-2,4-DICARBOXYLIC ACID (3 entities in total)
• 機能のキーワード: hepatitis, polymerase, hydrolase
• 由来する生物種: HEPATITIS C VIRUS
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 128543.21

構造登録者

Wonacott, A.,Skarzynski, T.,Singh, O.M. (登録日: 2006-12-18, 公開日: 2007-02-13, 最終更新日: 2011-07-13)

• 主引用文献: Slater, M.J.,Amphlett, E.M.,Andrews, D.M.,Bravi, G.,Burton, G.,Cheasty, A.G.,Corfield, J.A.,Ellis, M.R.,Fenwick, R.H.,Fernandes, S.,Guidetti, R.,Haigh, D.,Hartley, C.D.,Howes, P.D.,Jackson, D.L.,Jarvest, R.L.,Lovegrove, V.L.,Medhurst, K.J.,Parry, N.R.,Price, H.,Shah, P.,Singh, O.M.,Stocker, R.,Thommes, P.,Wilkinson, C.,Wonacott, A.; Optimization of Novel Acyl Pyrrolidine Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase Leading to a Development Candidate.; J.Med.Chem., 50:897-, 2007; PubMed: 17269759; DOI: 10.1021/JM061207R

実験手法

X-RAY DIFFRACTION (2.2 Å)