2JAV

Human Kinase with pyrrole-indolinone ligand

Replaces:  2CL1

Summary for 2JAV

• Entry DOI: 10.2210/pdb2jav/pdb
• Related: 2CL1
• Descriptor: SERINE/THREONINE-PROTEIN KINASE NEK2, 5-[(Z)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE (3 entities in total)
• Functional Keywords: transferase, phosphorylation, nucleotide-binding, atp-binding, cell division, metal-binding, nuclear protein, serine/threonine-protein kinase, serine/threonine protein kinase, kinase, meiosis, mitosis, magnesium, cell cycle
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 32962.23

Authors

Pike, A.C.W.,Rellos, P.,Das, S.,Fedorov, O.,Papagrigoriou, E.,Debreczeni, J.E.,Turnbull, A.P.,Gorrec, F.,Bray, J.,Sundstrom, M.,Arrowsmith, C.H.,Edwards, A.,Weigelt, J.,von Delft, F.,Knapp, S. (deposition date: 2006-11-30, release date: 2006-12-04, Last modification date: 2023-12-13)

• Primary citation: Rellos, P.,Ivins, F.J.,Baxter, J.E.,Pike, A.C.W.,Nott, T.J.,Parkinson, D.-M.,Das, S.,Howell, S.,Fedorov, O.,Shen, Q.Y.,Fry, A.M.,Knapp, S.,Smerdon, S.J.; Structure and Regulation of the Human Nek2 Centrosomal Kinase; J.Biol.Chem., 282:6833-, 2007; PubMed: 17197699; DOI: 10.1074/JBC.M609721200

Experimental method

X-RAY DIFFRACTION (2.2 Å)