2J4E
THE ITP COMPLEX OF HUMAN INOSINE TRIPHOSPHATASE
Summary for 2J4E
Entry DOI | 10.2210/pdb2j4e/pdb |
Related | 2CAR |
Descriptor | INOSINE TRIPHOSPHATE PYROPHOSPHATASE, INOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | nucleotide metabolism, itp, imp, hydrolase, disease mutation, inosine triphosphate pyrophosphohydrolase, inosine triphosphatase deficiency |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm: Q9BY32 |
Total number of polymer chains | 8 |
Total formula weight | 177177.82 |
Authors | Stenmark, P.,Kursula, P.,Arrowsmith, C.,Berglund, H.,Busam, R.,Collins, R.,Edwards, A.,Ehn, M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Hallberg, B.M.,Holmbergschiavone, L.,Hogbom, M.,Kotenyova, T.,Landry, R.,Loppnau, P.,Magnusdottir, A.,Nilsson-Ehle, P.,Nyman, T.,Ogg, D.,Persson, C.,Sagemark, J.,Sundstrom, M.,Uppenberg, J.,Thorsell, A.G.,Schuler, H.,Van Den Berg, S.,Wallden, K.,Weigelt, J.,Nordlund, P. (deposition date: 2006-08-29, release date: 2006-09-20, Last modification date: 2023-12-13) |
Primary citation | Stenmark, P.,Kursula, P.,Flodin, S.,Graslund, S.,Landry, R.,Nordlund, P.,Schuler, H. Crystal Structure of Human Inosine Triphosphatase: Substrate Binding and Implication of the Inosine Triphosphatase Deficiency Mutation P32T. J.Biol.Chem., 282:3182-, 2007 Cited by PubMed: 17138556DOI: 10.1074/JBC.M609838200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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