Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2J4E

THE ITP COMPLEX OF HUMAN INOSINE TRIPHOSPHATASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006193	biological_process	ITP catabolic process
A	0009117	biological_process	nucleotide metabolic process
A	0009143	biological_process	nucleoside triphosphate catabolic process
A	0009204	biological_process	deoxyribonucleoside triphosphate catabolic process
A	0016787	molecular_function	hydrolase activity
A	0035870	molecular_function	dITP diphosphatase activity
A	0036220	molecular_function	ITP diphosphatase activity
A	0036222	molecular_function	XTP diphosphatase activity
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
A	0051276	biological_process	chromosome organization
B	0000166	molecular_function	nucleotide binding
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006193	biological_process	ITP catabolic process
B	0009117	biological_process	nucleotide metabolic process
B	0009143	biological_process	nucleoside triphosphate catabolic process
B	0009204	biological_process	deoxyribonucleoside triphosphate catabolic process
B	0016787	molecular_function	hydrolase activity
B	0035870	molecular_function	dITP diphosphatase activity
B	0036220	molecular_function	ITP diphosphatase activity
B	0036222	molecular_function	XTP diphosphatase activity
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
B	0051276	biological_process	chromosome organization
C	0000166	molecular_function	nucleotide binding
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006193	biological_process	ITP catabolic process
C	0009117	biological_process	nucleotide metabolic process
C	0009143	biological_process	nucleoside triphosphate catabolic process
C	0009204	biological_process	deoxyribonucleoside triphosphate catabolic process
C	0016787	molecular_function	hydrolase activity
C	0035870	molecular_function	dITP diphosphatase activity
C	0036220	molecular_function	ITP diphosphatase activity
C	0036222	molecular_function	XTP diphosphatase activity
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
C	0051276	biological_process	chromosome organization
D	0000166	molecular_function	nucleotide binding
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006193	biological_process	ITP catabolic process
D	0009117	biological_process	nucleotide metabolic process
D	0009143	biological_process	nucleoside triphosphate catabolic process
D	0009204	biological_process	deoxyribonucleoside triphosphate catabolic process
D	0016787	molecular_function	hydrolase activity
D	0035870	molecular_function	dITP diphosphatase activity
D	0036220	molecular_function	ITP diphosphatase activity
D	0036222	molecular_function	XTP diphosphatase activity
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
D	0051276	biological_process	chromosome organization
E	0000166	molecular_function	nucleotide binding
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006193	biological_process	ITP catabolic process
E	0009117	biological_process	nucleotide metabolic process
E	0009143	biological_process	nucleoside triphosphate catabolic process
E	0009204	biological_process	deoxyribonucleoside triphosphate catabolic process
E	0016787	molecular_function	hydrolase activity
E	0035870	molecular_function	dITP diphosphatase activity
E	0036220	molecular_function	ITP diphosphatase activity
E	0036222	molecular_function	XTP diphosphatase activity
E	0042802	molecular_function	identical protein binding
E	0046872	molecular_function	metal ion binding
E	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
E	0051276	biological_process	chromosome organization
F	0000166	molecular_function	nucleotide binding
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006193	biological_process	ITP catabolic process
F	0009117	biological_process	nucleotide metabolic process
F	0009143	biological_process	nucleoside triphosphate catabolic process
F	0009204	biological_process	deoxyribonucleoside triphosphate catabolic process
F	0016787	molecular_function	hydrolase activity
F	0035870	molecular_function	dITP diphosphatase activity
F	0036220	molecular_function	ITP diphosphatase activity
F	0036222	molecular_function	XTP diphosphatase activity
F	0042802	molecular_function	identical protein binding
F	0046872	molecular_function	metal ion binding
F	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
F	0051276	biological_process	chromosome organization
G	0000166	molecular_function	nucleotide binding
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006193	biological_process	ITP catabolic process
G	0009117	biological_process	nucleotide metabolic process
G	0009143	biological_process	nucleoside triphosphate catabolic process
G	0009204	biological_process	deoxyribonucleoside triphosphate catabolic process
G	0016787	molecular_function	hydrolase activity
G	0035870	molecular_function	dITP diphosphatase activity
G	0036220	molecular_function	ITP diphosphatase activity
G	0036222	molecular_function	XTP diphosphatase activity
G	0042802	molecular_function	identical protein binding
G	0046872	molecular_function	metal ion binding
G	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
G	0051276	biological_process	chromosome organization
H	0000166	molecular_function	nucleotide binding
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006193	biological_process	ITP catabolic process
H	0009117	biological_process	nucleotide metabolic process
H	0009143	biological_process	nucleoside triphosphate catabolic process
H	0009204	biological_process	deoxyribonucleoside triphosphate catabolic process
H	0016787	molecular_function	hydrolase activity
H	0035870	molecular_function	dITP diphosphatase activity
H	0036220	molecular_function	ITP diphosphatase activity
H	0036222	molecular_function	XTP diphosphatase activity
H	0042802	molecular_function	identical protein binding
H	0046872	molecular_function	metal ion binding
H	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
H	0051276	biological_process	chromosome organization

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 1002

Chain	Residue
A	GLU44
A	LYS56
A	ITT1001

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG B 1002

Chain	Residue
B	GLU44
B	ITT1001

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG C 1002

Chain	Residue
C	LEU42
C	GLU44
C	ITT1001

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG D 1002

Chain	Residue
D	POP1000
D	GLU44

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG E 1002

Chain	Residue
E	GLU44
E	LYS89
E	ITT1001

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG F 1002

Chain	Residue
F	GLU44
F	ITT1001

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG G 1002

Chain	Residue
G	GLU44
G	LYS89
G	ITT1001

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG H 1002

Chain	Residue
H	GLU44
H	ITT1001

site_id	AC9
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ITT A 1001

Chain	Residue
A	THR14
A	GLY15
A	ASN16
A	LYS19
A	GLU44
A	LYS56
A	GLU71
A	ASP72
A	THR73
A	LYS89
A	PHE149
A	TRP151
A	ASP152
A	LYS172
A	HIS177
A	ARG178
A	MG1002

site_id	BC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ITT B 1001

Chain	Residue
B	THR14
B	GLY15
B	ASN16
B	LYS19
B	GLU44
B	LYS56
B	THR73
B	LYS89
B	LEU92
B	PHE149
B	GLY150
B	TRP151
B	ASP152
B	LYS172
B	HIS177
B	ARG178
B	MG1002

site_id	BC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ITT C 1001

Chain	Residue
C	THR14
C	GLY15
C	ASN16
C	LYS19
C	GLU44
C	LYS56
C	ASP72
C	THR73
C	LYS89
C	PHE149
C	TRP151
C	ASP152
C	LYS172
C	HIS177
C	ARG178
C	MG1002
C	HOH2026

site_id	BC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE POP D 1000

Chain	Residue
D	THR14
D	GLY15
D	ASN16
D	LYS19
D	GLU44
D	LYS56
D	LYS89
D	IMP1001
D	MG1002
D	HOH2030

site_id	BC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE IMP D 1001

Chain	Residue
D	ASN16
D	LYS19
D	GLU22
D	GLU71
D	ASP72
D	THR73
D	ILE88
D	LYS89
D	PHE149
D	TRP151
D	ASP152
D	LYS172
D	HIS177
D	ARG178
D	POP1000

site_id	BC5
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ITT E 1001

Chain	Residue
E	LYS19
E	GLU44
E	LYS56
E	GLU71
E	ASP72
E	THR73
E	LYS89
E	PHE149
E	GLY150
E	TRP151
E	ASP152
E	LYS172
E	HIS177
E	ARG178
E	MG1002
E	HOH2009
E	HOH2029
E	THR14
E	GLY15
E	ASN16

site_id	BC6
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ITT F 1001

Chain	Residue
F	THR14
F	GLY15
F	ASN16
F	LYS19
F	GLU44
F	LYS56
F	GLU71
F	THR73
F	LYS89
F	LEU92
F	PHE149
F	TRP151
F	ASP152
F	LYS172
F	HIS177
F	ARG178
F	MG1002

site_id	BC7
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ITT G 1001

Chain	Residue
G	THR14
G	GLY15
G	ASN16
G	LYS19
G	LYS56
G	ASP72
G	THR73
G	ILE88
G	PHE149
G	GLY150
G	TRP151
G	ASP152
G	LYS172
G	HIS177
G	ARG178
G	MG1002

site_id	BC8
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ITT H 1001

Chain	Residue
H	THR14
H	GLY15
H	ASN16
H	LYS19
H	GLU44
H	LYS56
H	THR73
H	ILE88
H	LYS89
H	PHE149
H	TRP151
H	ASP152
H	LYS172
H	HIS177
H	ARG178
H	MG1002

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	64
Details	BINDING: BINDING => ECO:0000269\|PubMed:17138556, ECO:0007744\|PDB:2J4E

Chain	Residue	Details
A	THR14
B	GLU44
B	LYS56
B	ASP72
B	LYS89
B	PHE149
B	LYS172
B	HIS177
C	THR14
C	GLU44
C	LYS56
A	GLU44
C	ASP72
C	LYS89
C	PHE149
C	LYS172
C	HIS177
D	THR14
D	GLU44
D	LYS56
D	ASP72
D	LYS89
A	LYS56
D	PHE149
D	LYS172
D	HIS177
E	THR14
E	GLU44
E	LYS56
E	ASP72
E	LYS89
E	PHE149
E	LYS172
A	ASP72
E	HIS177
F	THR14
F	GLU44
F	LYS56
F	ASP72
F	LYS89
F	PHE149
F	LYS172
F	HIS177
G	THR14
A	LYS89
G	GLU44
G	LYS56
G	ASP72
G	LYS89
G	PHE149
G	LYS172
G	HIS177
H	THR14
H	GLU44
H	LYS56
A	PHE149
H	ASP72
H	LYS89
H	PHE149
H	LYS172
H	HIS177
A	LYS172
A	HIS177
B	THR14

site_id	SWS_FT_FI2
Number of Residues	8
Details	MOD_RES: N-acetylalanine => ECO:0000255\|HAMAP-Rule:MF_03148, ECO:0000269\|Ref.9

Chain	Residue	Details
A	ALA2
B	ALA2
C	ALA2
D	ALA2
E	ALA2
F	ALA2
G	ALA2
H	ALA2

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)