2J4E

THE ITP COMPLEX OF HUMAN INOSINE TRIPHOSPHATASE

Summary for 2J4E

• Entry DOI: 10.2210/pdb2j4e/pdb
• Related: 2CAR
• Descriptor: INOSINE TRIPHOSPHATE PYROPHOSPHATASE, INOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: nucleotide metabolism, itp, imp, hydrolase, disease mutation, inosine triphosphate pyrophosphohydrolase, inosine triphosphatase deficiency
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm: Q9BY32
• Total number of polymer chains: 8
• Total formula weight: 177177.82

Authors

Stenmark, P.,Kursula, P.,Arrowsmith, C.,Berglund, H.,Busam, R.,Collins, R.,Edwards, A.,Ehn, M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Hallberg, B.M.,Holmbergschiavone, L.,Hogbom, M.,Kotenyova, T.,Landry, R.,Loppnau, P.,Magnusdottir, A.,Nilsson-Ehle, P.,Nyman, T.,Ogg, D.,Persson, C.,Sagemark, J.,Sundstrom, M.,Uppenberg, J.,Thorsell, A.G.,Schuler, H.,Van Den Berg, S.,Wallden, K.,Weigelt, J.,Nordlund, P. (deposition date: 2006-08-29, release date: 2006-09-20, Last modification date: 2023-12-13)

• Primary citation: Stenmark, P.,Kursula, P.,Flodin, S.,Graslund, S.,Landry, R.,Nordlund, P.,Schuler, H.; Crystal Structure of Human Inosine Triphosphatase: Substrate Binding and Implication of the Inosine Triphosphatase Deficiency Mutation P32T.; J.Biol.Chem., 282:3182-, 2007; PubMed: 17138556; DOI: 10.1074/JBC.M609838200

Experimental method

X-RAY DIFFRACTION (2.8 Å)