2J25

Partially deglycosylated glucoceramidase

2J25 の概要

• エントリーDOI: 10.2210/pdb2j25/pdb
• 関連するPDBエントリー: 1OGS 1Y7V 2F61
• 分子名称: GLUCOSYLCERAMIDASE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: pharmaceutical, gaucher disease, disease mutation, glycosidase, sphingolipid, polymorphism, glycoprotein, membrane, lysosome, hydrolase, glucosidase, glucocerebrosidase, alternative initiation, lipid metabolism, cerezyme hydrolase, sphingolipid metabolism
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 115480.78

構造登録者

Brumshtein, B.,Wormald, M.R.,Silman, I.,Futerman, A.H.,Sussman, J.L. (登録日: 2006-08-16, 公開日: 2006-12-06, 最終更新日: 2023-12-13)

• 主引用文献: Brumshtein, B.,Wormald, M.R.,Silman, I.,Futerman, A.H.,Sussman, J.L.; Structural Comparison of Differently Glycosylated Forms of Acid-Beta-Glucosidase, the Defective Enzyme in Gaucher Disease; Acta Crystallogr.,Sect.D, 62:1458-, 2006; PubMed: 17139081; DOI: 10.1107/S0907444906038303

実験手法

X-RAY DIFFRACTION (2.9 Å)