2J1W
Human p53 core domain mutant M133L-V143A-V203A-N239Y-N268D
Summary for 2J1W
Entry DOI | 10.2210/pdb2j1w/pdb |
Related | 1HU8 1UOL 2BIM 2BIN 2BIO 2BIP 2BIQ 2J1X 2J1Y 2J1Z 2J20 2J21 |
Descriptor | CELLULAR TUMOR ANTIGEN P53, ZINC ION (3 entities in total) |
Functional Keywords | second-site suppressor mutation, disease mutation, nuclear protein, phosphorylation, tumor suppressor, alternative splicing, li-fraumeni syndrome, li- fraumeni syndrome, host-virus interaction, transcription, metal-binding, anti-oncogene, dna-binding, transferase, polymorphism, glycoprotein, zinc, activator, apoptosis, cell cycle, acetylation, p53 dna-binding domain, transcription regulation, superstable mutant, dna-binding protein |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637 |
Total number of polymer chains | 2 |
Total formula weight | 49256.40 |
Authors | Joerger, A.C.,Fersht, A.R. (deposition date: 2006-08-15, release date: 2006-09-20, Last modification date: 2023-12-13) |
Primary citation | Joerger, A.C.,Ang, H.C.,Fersht, A.R. Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.USA, 103:15056-, 2006 Cited by PubMed: 17015838DOI: 10.1073/PNAS.0607286103 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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